Lumbricus rubellus Protein Fraction DLBS1033N Increases Nerve Growth Factor Expression via Tyrosine Kinase Activation
نویسندگان
چکیده
منابع مشابه
Nerve growth factor induces protein-tyrosine phosphorylation.
When the sympathetic nerve-like cell line PC12 is exposed to nerve growth factor (NGF), there is a rapid and transient phosphorylation of tyrosine residues in cellular proteins, as demonstrated by immunoblotting of cell extracts with high-affinity polyclonal antibodies specific for phosphotyrosine residues. Epidermal growth factor (EGF), which does not cause the morphological differentiation of...
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متن کاملProtein tyrosine phosphatase activation during nerve growth factor-induced neuronal differentiation of PC12 cells.
We have studied the role of protein tyrosine phosphatases (PTPases) during neuronal differentiation of PC12 cells. Nerve growth factor (NGF), a well-characterized differentiating agent for these cells, led to a decrease in DNA synthesis within 24 h. This was accompanied by a 2- to 3-fold increase in the activity of PTPases, measured as the dephosphorylation of polyacidic or polybasic substrates...
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ژورنال
عنوان ژورنال: American Journal of Biochemistry and Biotechnology
سال: 2018
ISSN: 1553-3468
DOI: 10.3844/ajbbsp.2018.29.38